Alzheimer's Disease Education and Referral Center

Search for Clinical Trials

Your Search Identified 70 Trial(s):

  • 1. AC-1204 for Mild to Moderate Alzheimer's Disease

    Purpose: To evaluate the effects of AC-1204 on cognition, activities of daily living, quality of life, pharmacokinetic measures, and safety in people with mild to moderate Alzheimer's disease.

  • 2. Aerobic & Cognitive Exercise Study (ACES)

    Purpose: To clarify the benefits to brain health and thinking processes that result from different forms of exercise.

  • 3. Alzheimer's Caregiver Coping: Mental and Physical Health

    Purpose: To compare two intervention strategies for reducing emotional and cardiovascular disease risk in Alzheimer's caregivers.

  • 4. Alzheimer's Disease Genetics Study

    Purpose: To identify the genes that are responsible for causing Alzheimer's disease by collecting genetic material from families with multiple members diagnosed with Alzheimer's disease.

  • 5. Alzheimer's Disease Multiple Intervention Trial

    Purpose: To improve functioning among older adults with Alzheimer's disease by comparing a control group receiving best practices primary care with an intervention group receiving best practice primary care plus a home-based occupational therapy intervention.

  • 6. Alzheimer's Prevention Through Exercise

    Purpose: To learn about the possible benefits of aerobic exercise for individuals at risk of developing Alzheimer's disease.

  • 7. Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4)

    Purpose: To test whether an anti-amyloid investigational drug, solanezumab, can slow memory and cognitive decline in older individuals who do not yet show symptoms of Alzheimer's disease cognitive impairment or dementia.

  • 8. Arterial Spin Labeling (ASL) MRI for Cognitive Decline

    Purpose: To determine the value of arterial spin labeling magnetic resonance imaging, a measure of blood flow to the brain, in finding the cause of cognitive decline in people with mild cognitive impairment.

  • 9. AZD0530 in Mild Alzheimer's Disease (Connect Study)

    Purpose: To determine the safety and efficacy of the experimental drug AZD0530 in older adults with mild Alzheimer's disease.

  • 10. AZD3293 in Early Alzheimer's Disease (AMARANTH)

    Purpose: To assess the efficacy and safety of AZD3293 as a possible treatment for early Alzheimer´s disease.

  • 11. BAN2401 for Early Alzheimer's Disease

    Purpose: To determine the effectiveness of the experimental drug BAN2401 as a possible treatment for people with mild cognitive impairment or mild Alzheimer's disease.

  • 12. Behavioral Interventions to Prevent or Delay Dementia

    Purpose: To compare the effectiveness of different combinations of five behavioral interventions in people with amnestic mild cognitive impairment.

  • 13. Brain Alterations and Cognitive Impairment in Older Adults with Heart Failure

    Purpose: To study the relationship between brain MRI results and cognitive impairment in older adults with heart failure.

  • 14. Brexpiprazole for Agitation in Alzheimer's Dementia

    Purpose: To assess the efficacy of the experimental drug brexpiprazole in people with agitation due to Alzheimer's dementia.

  • 15. Carvedilol in Alzheimer's Disease

    Purpose: To determine whether carvedilol treatment is associated with improvement in Alzheimer's disease compared to a placebo.

  • 16. Cholinesterase Inhibitor Discontinuation

    Purpose: To determine if stopping certain medications for Alzheimer's disease will cause worsened cognition, functioning, or behavior in veterans with advanced dementia.

  • 17. Clinical Evaluation of Florbetapir F 18 (18F-AV-45)

    Purpose: To standardize imaging studies using florbetapir F 18 PET to provide information on amyloid burden.

  • 18. Coconut Oil for Alzheimer's Disease

    Purpose: To determine the efficacy of coconut oil as a possible treatment for mild to moderate Alzheimer's disease.

  • 19. Cognitive Training and Practice Effects in MCI

    Purpose: To test the effectiveness of a computerized cognitive (thinking) training program in people with mild cognitive impairment.

  • 20. Cognitive Video Game Performance in Healthy Older Adults

    Purpose: To evaluate the difference in learning and performance measures associated with using a video game in healthy older adults.

  • 21. Crenezumab for Mild to Moderate Alzheimer Disease

    Purpose: To evaluate the safety and tolerability of crenezumab in older adults with mild to moderate Alzheimer's disease.

  • 22. Curcumin and Yoga Therapy for Mild Cognitive Impairment

    Purpose: To test the clinical benefits of curcumin, a compound isolated from turmeric root, and a yoga-based physical exercise program in individuals with early memory problems.

  • 23. Dominantly Inherited Alzheimer Network (DIAN)

    Purpose: To identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.

  • 24. Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia (DIAN TU)

    Purpose: To assess the safety, tolerability, and biomarker efficacy of gantenerumab and solanezumab in individuals who have a genetic mutation for autosomal-dominant Alzheimer's disease.

  • 25. E2609 for Mild Cognitive Impairment Due to Alzheimer's Disease

    Purpose: To evaluate the safety and efficacy of the experimental drug E2609 in people with mild cognitive impairment or mild dementia due to Alzheimer's disease.

  • 26. Early Detection and Prevention of Mild Cognitive Impairment Due to Cerebrovascular Disease

    Purpose: To study vascular risk factors that cause memory and thinking problems and ways to control these risk factors.

  • 27. EEG Guidance of Anesthesia to Alleviate Geriatric Syndromes (ENGAGES)

    Purpose: To determine whether, compared with usual anesthetic care, an EEG-guided anesthesia protocol can prevent delirium after surgery.

  • 28. Effect of Blueberries on Cognition and Body Composition in Elderly with Mild Cognitive Decline

    Purpose: To examine the effect of blueberry consumption on cognitive decline and body composition in older adults with mild cognitive decline.

  • 29. Effect of NeuroAD on Cognitive Function in Alzheimer's Disease

    Purpose: To test the effect of NeuroAD, a noninvasive device that delivers magnetic stimulation to the brain, on cognition in people with Alzheimer's disease.

  • 30. Effects of a Lutein Supplement on Cognitive Function

    Purpose: To determine the effects of taking lutein, a dietary supplement, on cognition in adults of all ages.

  • 31. Effects of Anesthesia on Cognition and Alzheimer's Disease Biomarkers

    Purpose: To evaluate the effects of surgical anesthesia on cognition and certain Alzheimer's disease biomarkers in older adults who undergo surgery.

  • 32. Effects of Atomoxetine in Mild Cognitive Impairment

    Purpose: To find out if atomoxetine causes a change in the biomarkers (substances that may indicate the presence of a disease) in the cerebrospinal fluid of people diagnosed with mild cognitive impairment.

  • 33. Effects of Brain Beta-Amyloid on Postoperative Cognition

    Purpose: To determine if the presence of beta-amyloid plaques in the brains of non-demented patients before hip or knee replacement surgery predicts cognitive decline after surgery.

  • 34. Effects of Donepezil Measured by Functional MRI

    Purpose: To examine the sensitivity of functional MRI to detect brain changes in healthy older adults at genetic risk for Alzheimer's disease who take donepezil (Aricept).

  • 35. Effects of Fruitflow-II and Resveratrol on Memory, Fitness, and Cerebral Blood Flow

    Purpose: To determine if Fruitflow-II (a tomato extract), resveratrol (a compound found in some foods), alone or in combination, can effectively treat memory problems in older adults with memory impairment.

  • 36. ELND005 for Agitation and Aggression in Alzheimer's Disease

    Purpose: To determine whether ELND005 is effective in treating symptoms of agitation and aggression in people with Alzheimer's disease.

  • 37. Evaluation of Tracers for Positron Emission Tomography (PET) Imaging of Tau

    Purpose: To obtain basic information about three PET imaging tracers developed to detect tau pathology in the brain.

  • 38. EVP-6124 for Treating Alzheimer's Disease

    Purpose: To evaluate the safety and efficacy of EVP-6124 as a potential treatment for mild to moderate Alzheimer's disease.

  • 39. Exendin-4 in Alzheimer's Disease

    Purpose: To determine the safety and effectiveness of twice daily administration of Exendin-4 as a treatment for early-stage Alzheimer's disease or mild cognitive impairment.

  • 40. FRM-0334 for Frontotemporal Dementia with a Granulin Mutation

    Purpose: To investigate the safety, tolerability, and pharmacodynamics of the experimental drug FRM-0334 in people with early to moderate frontotemporal dementia with a granulin mutation.

  • 41. Gantenerumab for Mild Alzheimer Disease

    Purpose: To evaluate the efficacy and safety of the experimental drug gantenerumab as a possible treatment for people with mild Alzheimer disease.

  • 42. Gemfibrozil in Predementia Alzheimer's Disease

    Purpose: To assess the drug gemfibrozil for the prevention of Alzheimer's disease.

  • 43. Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT)

    Purpose: To learn more about biomarkers and their relationship to aging.

  • 44. Human Brain Antioxidants During Oxidative Stress

    Purpose: To evaluate the level of two antioxidants in the brain as humans with and without Alzheimer's disease get older.

  • 45. Improving Dementia Caregiver Sleep and the Effect on Heart Disease Biomarkers

    Purpose: To determine whether a combined intervention of a nighttime home monitoring system and cognitive-behavioral therapy for insomnia is effective in improving sleep in dementia caregivers who arise at night.

  • 46. Indiana University Dementia Screening Trial

    Purpose: To assess the harms and benefits of screening for dementia, compared to no screening for dementia, among older adults in a primary care setting.

  • 47. Language in Primary Progressive Aphasia

    Purpose: To further define the neurological and linguistic deterioration in primary progressive aphasia.

  • 48. Lidocaine for Neuroprotection During Cardiac Surgery

    Purpose: To see if the drug lidocaine can prevent cognitive decline after heart surgery.

  • 49. Living with Frontotemporal Dementia

    Purpose: To better understand the experience of people with frontotemporal dementia and their caregivers in order to develop better therapies.

  • 50. MEDI1814 for Mild to Moderate Alzheimer's Disease

    Purpose: To assess the safety and efficacy of the drug MEDI1814 in people with mild to moderate Alzheimer's disease.

  • 51. Memory Consolidation in Obstructive Sleep Apnea

    Purpose: To test the use of continuous positive airway pressure (CPAP) to reverse some or all memory deficits in people with obstructive sleep apnea.

  • 52. Mild Cognitive Impairment in Breast Cancer

    Purpose: To study how women undergoing breast cancer treatment may develop brain changes related to the development of mild cognitive impairment.

  • 53. MK-7622 in People with Alzheimer's Disease Taking Donepezil

    Purpose: To test the efficacy and safety of MK-7622 as an add-on therapy to donepezil in people with mild to moderate Alzheimer's disease.

  • 54. MK-8931 for Amnestic Mild Cognitive Impairment (APECS)

    Purpose: To assess MK-8931 as a possible treatment for amnestic mild cognitive impairment due to Alzheimer's disease.

  • 55. MK-8931 for Mild to Moderate Alzheimer's Disease

    Purpose: To assess the efficacy and safety of MK-8931 as a possible treatment for Alzheimer's disease.

  • 56. Natural History of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

    Purpose: To characterize the natural history of disease in people who carry a repeat expansion in the C9ORF72 gene, which causes amyotrophic lateral sclerosis and frontotemporal dementia.

  • 57. NOBLE: T-817MA for Mild to Moderate Alzheimer's Disease

    Purpose: To evaluate the efficacy of the experimental drug T-817MA as a potential treatment for people with mild to moderate Alzheimer's disease.

  • 58. Nuedexta for Treating Pseudobulbar Affect in Alzheimer's Disease

    Purpose: To test the safety and effectiveness of the drug Nuedexta (dextromethorphan/quinidine) as a treatment for pseudobulbar affect in people with Alzheimer's disease.

  • 59. Olfactory Deficits and Donepezil Treatment in Cognitively Impaired Older Adults

    Purpose: To determine if a worsened sense of smell can identify older people who might benefit from treatment with the Alzheimer's drug donepezil.

  • 60. PET Imaging with 18F-AV-1451

    Purpose: To evaluate the characteristics of the brain imaging agent 18F-AV-1451 in cognitively healthy volunteers and in people with mild cognitive impairment or Alzheimer's disease.

  • 61. PET Imaging with [18F]XTRA

    Purpose: To test the ability of the imaging agent [18F]XTRA to detect early brain changes in neurodegenerative diseases such as Alzheimer's.

  • 62. Progress of Mild Alzheimer's Disease with Solanezumab (EXPEDITION3)

    Purpose: To determine if the drug solanezumab will slow cognitive and functional decline in older adults with mild Alzheimer's disease.

  • 63. Promoting Adaptive Neuroplasticity in Mild Cognitive Impairment

    Purpose: To test the effects of transcranial direct current stimulation on memory in people with mild cognitive impairment.

  • 64. Rasagiline in Alzheimer's Disease

    Purpose: To evaluate the effect of the drug rasagiline on brain metabolism in people with mild to moderate Alzheimer's disease.

  • 65. Reducing Agitation in People with Dementia

    Purpose: To test a nonpharmacologic intervention, the Tailored Activity Program, for reducing agitation in people with dementia.

  • 66. Reliability of the Human Brain Connectome

    Purpose: To use magnetic resonance imaging to investigate brain function and connections in healthy adults.

  • 67. Sleep-Disordered Breathing and Alzheimer's Disease Prevention (SNAP)

    Purpose: To examine the relationship between sleep-disordered breathing and Alzheimer's disease in cognitive normal older adults.

  • 68. SUVN-G3031 Safety, Tolerability, and Pharmacokinetics

    Purpose: To investigate the safety, tolerability and pharmacokinetics of SUVN-G3031 in healthy subjects.

  • 69. Transcranial Magnetic Stimulation to Treat Alzheimer's

    Purpose: To test transcranial magnetic stimulation as a treatment for Alzheimer's disease.

  • 70. VA Cultivating Access to Resources, Education, and Skills for Dementia Caregivers (VA CARES)

    Purpose: To study the effects of an education and skill-building intervention on family caregivers of veterans with dementia.

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